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KMID : 0605620060130030137
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Journal of Korean Society of Biological Psychiatry
2006 Volume.13 No. 3 p.137 ~ p.143
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P50 and Schizophrenia
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Lee Seung-Hwan
Chung Young-Cho
Seo Hyung-Seok
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Abstract
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One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain’s sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.
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KEYWORD
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P50, Event-related potential, ERP, Schizophrenia
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